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313 Several therapeutic approaches targeting Met metabolism, including Met restriction, MAT2A inhibitors IDE397 and AG-270, are in clinical trials, and their therapeutic effects need to be verified

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Mechanism-based inactivation, the structure of reactive metabolitesMBI relationships, should be applied in clinical to mitigate the risk of idiosyncratic drug toxicity ( 5 Novel Analytical Techniques Used for Detection of the Reactive Metabolites of Natural Products Metabolic activation of a natural product resulting in reactive metabolite(s) that can covalently modify proteins is considered an initial step that may lead to drug-induced organ toxicities, therefore, detecting and characterizing of reactive metabolites will provide a useful clue for predicting metabolic activation mediated toxicity