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It acts on both GLP-1 and GIP receptors and has become a central reference compound in metabolic research, especially in models of appetite regulation, body-weight change, glycaemic control and incretin signalling

Serious allergic reactions happen in less than 1% of cases but can include throat swelling, severe rash, and breathing difficulty requiring immediate emergency care

These limitations do not invalidate preclinical findings but emphasize the need for human clinical trials with appropriate sample sizes, standardized protocols, and validated outcome measures before establishing clinical efficacy in human patients

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Under normal conditions, the spinal canal typically provides sufficient space for the spinal cord and nerves to move without compression