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Inhibitory actions of opiates and synthetic opioids on secretomotor neurons and cholinergic neurotransmission in the ENS account for much of their constipating action

It is therefore crucial that clinicians probe into this issue when assessing men presenting with ED and/or lower urinary tract symptoms (LUTS), as they can co-exist with PD

the agents described herein can be employed in a method including the step of providing a reducing agent-choline ester active agent to a cell, either in vitro or in vivo

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