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Life Extension SAMe SAdenosylMethionine, 400mg 60 enteric coated tabs TENA Discreet Extra Incontinence pad Vitamin E to improve theOur Best Seller SAMe, or S Adenosyl Methionine, benefits many critical metabolic functions in the body. This amazing compound helps maintain a stable mood and supports both joint and liver health. SAMe participates in many critical metabolic functions by donating methyl groups to other molecules. Methyl groups need to be transferred between compounds in the body to help with things like neurotransmitter signaling and protein function. Laboratory