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Furthermore, immune dysfunction leads to altered balance within the immune pathways resulting in excess inflammation

A General 143 , 383430 (1980)

The 20 to 35 years old participants received 200 mg Pycnogenol per day or placebo for 30 days, then switched to the other group for another 30 days

This could introduce challenges for patients with lifelong anticoagulation needs, such as those with heart failure and atrial fibrillation (Yasueda et al., 2016) and could interact with antihypertensive drugs to cause an excessive drop in blood pressure, necessitating careful monitoring and dose adjustments (Zhao et al., 2022)