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Numerous studies have demonstrated the therapeutic potential of strategies targeting mitophagy to regulate RCD, and related drugs have shown promise in the treatment of various diseases (Table 1)

However, I have strong reservations and concerns about self-injection of non-FDA-approved or compounded peptides that carry significant risks, including contamination, dosing errors and serious adverse events such as compartment syndrome (dangerous muscle pressure buildup) that can lead to surgery or even death, as documented by FDA reports

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Energetic intake should be provided by infusion of dextrose 1030% and a 20% fat emulsion (Intralipid) to provide supranormal caloric intake to avoid catabolism with a transition as soon as possible to an oral diet with anti-emetics if necessary