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In contrast to the lack of brain entry of dopamine in vivo [68], our results with the targeted dopamine-nanoformulation using the BBB model combined with midbrain organoids indicate that the nanoformulation may help dopamine to reach the brain tissue after BBB penetration

Regarding the impact of NIF on MTX-induced intestinal injury, NIF exhibited potent antioxidant benefits against MTX-provoked intestinal injury by controlling PPAR-, SIRT1, and Nrf2 redox-sensitive signals expression (Abd-Alhameed et al