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Once internalized, a portion of the long peptides is degraded through the endosomal pathway, loaded onto MHC class II molecules, and recognized by CD4 + T helper cells

While SCA3 has an adult onset, alterations in the CNS precede symptom appearance [166, 167]: therefore, correcting the mutation in ATXN3 in the disease state might not be fully beneficial, as neurons could already have irreversible changes