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High frequency alternating current generates thermal energy through ionic vibration, leading to the evaporation of water and the ablution of cells, perhaps causing harm to underlying tissue

10.1042/cs20160604 75 Santos-CancelM.SimpsonL

Minimal reported adverse effects but lacks Phase 3 validation

Arginosuccinate synthetase is a key enzyme in urea cycle, and deficiency of this enzyme leads to inability to catalyze the formation of argininosuccinic acid

Critical illness Tesamorelin labeling warns about increased mortality observed with pharmacologic GH in acute critical illness and advises considering discontinuation in critically ill patients