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Impaired Metabolism of Selenome-thionine in Graves Disease: A Biokinetics Study of Soft Gel Capsule Formulation

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Di Marzio L, Moretti S, D'Alo S, Zazzeroni F, Marcellini S, Smacchia C, Alesse E, Cifone MG, De Simone C

FIGURE 5 6 Implications for drug toxicity and personalized medicine The exposome-encompassing environmental exposures, lifestyle factors, and genetic interactions-profoundly influences CYP450 enzyme activity, creating variability in drug response and toxicity, which necessitates advanced strategies for personalized medicine that integrates genetic, biomarker, and environmental data to optimize therapeutic outcomes

Additionally, the skin cells neighboring melanocytes, mainly keratinocytes, have also been identified as a source of ROS via transferring HO to melanocytes 51