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The low cost of the older first-generation antipsychotic drugs contributes to their widespread use despite their risk of adverse EPS effects (2)

We hypothesized that age-dependent elevation of labile iron, coupled with a reduction of glutathione levels conspire to lower the threshold for ferroptotic signaling, increasing the vulnerability of aged animals and implying that disruption to the iron-glutathione axis is fundamental to natural ageing and death

Science 360 , 449453 (2018)

10.1089/ars.2017.7462 Antioxid Redox Signal

Conclusion: BA patients have persistent IL-8-CXCR2-mediated NET formation that correlates with biomarkers of injury and fibrosis and NETs induce stellate cell activation, suggesting a role for NETs in the immunopathogenesis of disease