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The big downside of this ingredient is formulation difficulty

10.3390/ijms19071987 38 PickartL.Vasquez-SolteroJ

Contamination risk with compounded/DIY products: This is the bigger practical concern

The hair-growth interest comes from a line of animal research: T4 was shown to increase hair growth in rats and mice by activating hair-follicle stem cells in the bulge region, per PubMed (Philp et al., 2003, DOI), with follow-up work showing faster regrowth in T4-overexpressing mice and slower regrowth in knockout mice via VEGF and P38/ERK/AKT signalling (Gao et al., 2015, DOI)

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