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9 Limitations of preclinical evidence Despite the growing body of preclinical evidence supporting the neuroprotective potential of astaxanthin, several important limitations should be acknowledged

642 Astrocytes obtained form stem cells isolated from patients with PD linked to LRRK2/dardarin mutation showed prominent morphological atrophy, 113 as well as decreased expression of glutamate transporters, 643 and prominent mitochondrial deficiencies

For the polyglutamylation to be effective and to achieve tissue retention, 5-methyl-THF needs to be first metabolized to THF via the methionine cycle

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doi: 10.1042/BSR20181614