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Management generally involves levothyroxine replacement therapy, complemented in some cases by dietary optimization and micronutrient supplementation

An et al., 2017)

Nephropathy and kidney stones

Blocking channels to metastasis: targeting sodium transport in breast cancer

This conformational change induced by the allosteric inhibitor is distinguished from that of substrate- or competitive inhibitor-binding, where the C-terminal domain rotates inward for 34 compared with the unbound form of Rv1098c