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For insulin resistance and prediabetes, steadier post-meal blood sugar supports the broader plan, as outlined by the NIDDK overview of obesity medications

and had normal 46,XY karyotype (Supplemental Figure 4, AD)

The effect measures estimated were relative risk (RR) for dichotomous data, and weighted mean difference (WMD) for continuous data, using 95% confidence intervals (CIs)

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