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In some embodiments, the compositions comprise at least about 30 M mitophagy stimulant (e.g., urolithin A)

TXNIP promotes apoptosis by disrupting the Trx1-ASK1 and Trx2-ASK1 complexes, leading to ASK1 activation, activation of the p38 MAPK and JNK pathways, and initiation of apoptotic cascades (46,48,49)

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Postherpetic neuralgia (PHN)severe nerve pain that occurs with the original rash and often outlasts it for months or yearsis the most common complication of shingles

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