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Severe deficiency: For extreme insufficiency and blood health problems like pernicious anemia, treatments with 1000 2000 mcg per day are prescribed

GPR3 is expressed in the brain, endocrine tissues, muscle, respiratory system, and digestive tract (Tissue expression of GPR3 - Summary - The Human Protein Atlas n.d), and GPR6 is expressed in the brain and endocrine tissues (Tissue expression of GPR6 - Summary - The Human Protein Atlas n.d)