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Furthermore, it has been shown that inhibition of mTOR could boost temozolomide-induced senescence, whereas autophagy inhibition triggered apoptosis and decreased senescence

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ChIP assays were performed using Kasumi-1 and K562 cells, as well as HEK293T cells transduced with GFP-ASXL1 1-645 -WT, GFP-ASXL1 1-645 -I574D, GFP-ASXL1 1-591 -WT or GFP-ASXL1 1-591 -I574D (5 10 cells per condition), following protocols 39

--| inhibit) Since KRAS mutations are known to cause many cancers at the genetic level, we now focus on some ongoing clinical trials and recently approved drugs targeting KRAS