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More importantly, current treatment approaches predominantly target individual diseases, overlooking the complex interactions under comorbid conditions: many antidepressant medications affect gastrointestinal function and may exacerbate constipation symptoms (Yun et al., 2024)

KPV and MOTS-C had no human studies at all

The autoimmune response in Graves disease is often accompanied by increased OS, which exacerbates thyroid tissue damage and may contribute to the development of thyroid eye disease (TED) [79]