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(Schmocker et al., 2016) developed a photocurable poly (ethylene glycol) dimethacrylate nanofibrillated cellulose composite hydrogel that can effectively restore intervertebral disc height, offering a new approach for partial replacement

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The copper content of GHK-Cu formulations has been a theoretical safety consideration, given that excessive copper can be toxic - however, the amounts used in cosmetic and research applications are extremely small, the copper is tightly chelated by the peptide (reducing free copper availability), and topical absorption of copper from these products appears minimal and well below levels that would cause systemic copper accumulation or toxicity

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