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Further research reveals that PCs, alone or in combination with other phytoalexins, can activate the AMPK/SIRT1/NF-B pathway and inhibit the miR-34a/SIRT1/p53 axis, thereby mitigating hyperglycemia-induced inflammation, oxidative stress, and apoptosis in retinal cells (Liu et al., 2021) (Figure 9)

This suggests that downregulation of MYC contributes to, but is not the sole mechanism of, growth inhibition by SPA/BAT