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Widely used rodent models, employing chronic hypoxia or monocrotaline (MCT), successfully capture key pathological hallmarks like pulmonary vascular remodeling and right ventricular hypertrophy

You F et al

In the aforementioned studies on the cellular and gene level effects, although various studies have yielded either positive or negative findings, in vitro experiments alone cannot fully capture the interplay of diverse bodily systems in response to external stimuli