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Importantly, these side effects are most prominent during treatment initiation and dose escalation periods, with median durations of 8 days for nausea, 3 days for diarrhea, and 2 days for vomiting

High blood pressure (HBP) is considered both a risk factor and a disease: HBP is a major risk factor for cardiovascular disease, increasing the likelihood of heart attack, stroke, heart failure, and atrial fibrillation

[7] N-acetylated LKKTETQ (Ac-LKKTETQ) and several of its metabolites can be detected in equine urine and plasma following administration of TB-500 using liquid chromatographymass spectrometry, with metabolite profiling enabling identification of peptide-derived products in biological samples

PMID: 14555532

Oxidative stress impairs mitochondrial integrity and disrupts ATP production, thereby causing energy deficiency and worsening fatigue