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Additional tests include liver function tests (ALT, AST, bilirubin, albumin), renal function tests, and potentially fibrosis risk scores such as FIB-4 or an Enhanced Liver Fibrosis (ELF) blood test if advanced liver disease is suspected

A washout period of at least several weeks is advisable, though specific recommendations cannot be made given limited data

A common approach is to add a volume of water that makes the math simple for future measurements

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We also found that some differential metabolites like trans-cinnamate and sphingosine 1-phosphate was significantly correlated with IL-13, IP-10, IFN-, and Eotaxin ( Padj 0.05), such as 3-hydroxyphenylacetate and prostaglandin H2, were also significantly correlated with IL-12, MCP-1 and IL-7 among patients with MS ( Padj 0.05) ( Figure S6 )