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In patients receiving clonidine to ameliorate OWS from heroin, dextromethorphan 60 mg (compared with placebo) showed improvements in OOWS scores during the later phase (days 36) of withdrawal

Additionally, sulforaphane increased NRF2 target gene expression and enhanced activity of antioxidant enzymes, including superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR)

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That creates the wrong kind of anxiety and often the wrong next step

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