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A follow-up trial in 2010 confirmed the 0.5mg dose as the optimal balance between efficacy and tolerability, producing 9.2% mean reduction with lower cardiovascular stimulation

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At 1 h after administration, [ 3 H]proline accounted for 86.65% of the plasma radioactive components

This leads to downstream signalling cascades involved in: Neurogenesis supports the proliferation and differentiation of neural stem cells