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[29] Up to this point, the hexose monophosphate shunt has generated the following, for each molecule of glucose 6-phosphate metabolized: a pool of three pentose 5-phosphates, ribulose 5-phosphate, ribose 5-phosphate, and xylulose 5-phosphate, which coexist at equilibrium

However, these complications need to be closely monitored and overcome, possibly by modern technologies, such as logic-gating circuits and synthetic biology approaches (223)