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1460-C BEPIROVIRSEN HAS INTRINSIC INNATE ACTIVITY, DISTINCT FROM THAT OF OTHER ANTI-SENSE OLIGONUCLEOTIDES Megan Ermler 1 , Kristen Jones 1 , Amitabh Das 1 , Anne DeHart 1 , Nicholas Galwey 1 , Melanie Paff 2 and Shihyun You 2 , (1)GSK, (2)GSK, Collegeville, PA, USA Background: Bepirovirsen (BPV) is an anti-sense oligonucleotide (ASO) that is in phase 3 clinical trials for chronic hepatitis B (CHB)

This elevates glycerol levels in liver cells, which gives rise to hepatic steatosis, inflammation, and eventually fibrosis

We will review how sleep impairments and brain metabolism affect each other and contribute to the aging process

While its indirect effects are highly pronounced in the arterial system, its direct vasoconstrictive action operates predominantly on the venous system, making it highly effective at elevating venous return and central venous pressure (Statler et al, 2023)

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