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Much of it is indirect, preclinical, observational, or focused on biomarkers rather than clinically meaningful outcomes [8][1012][1415]

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The April 2026 FDA reclassification has made legitimate access through licensed clinicians and compliant compounding pharmacies more straightforward than it has been in years

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Gastrointestinal effects are the most frequently reported side effects and include: Nausea (1224% of patients): Often most pronounced during treatment initiation and dose escalation, typically improving over time Diarrhea (1323% of patients): May be transient or persistent, requiring dietary modifications Vomiting (611% of patients): Can lead to dehydration if severe or prolonged Constipation (617% of patients): May require increased fiber intake and hydration Abdominal pain or discomfort (610% of patients): Usually mild to moderate in severity Decreased appetite : Therapeutic effect but may be excessive in some individuals These gastrointestinal symptoms generally diminish over several weeks as the body adjusts to the medication