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Zhou X, Ji W-J, Zhu Y et al (2007) Enhancement of endogenous defenses against ROS by supra-nutritional level of selenium is more safe and effective than antioxidant supplementation in reducing hypertensive target organ damage

Increased need An increased need for L-glutathione can occur, for example, with a low-protein diet, stress, high physical exertion, reduction diets, taking certain medicines and in old age

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By selectively engaging trophic, epigenetic, redox, immune, mechanosensory, vascular, and mitochondrial programs, these agents offer a means of extending the benefits of exercise to individuals who are unable to participate in sufficient physical training (Fig