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Although clinical data on ferroptosis induction remain limited, they are steadily increasing

The first successful and life-saving injection of insulin was given to 14-year-old Leonard Thompson, who had type 1 diabetes

Le Henaff C, Mansouri R, Modrowski D, Zarka M, Geoffroy V, Marty C, Tarantino N, Laplantine E, Marie PJ (2015) Increased NF-B Activity and Decreased Wnt/-Catenin Signaling Mediate Reduced Osteoblast Differentiation and Function in F508 Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mice

FASEB J 2003

This occurs when there is over-activation of receptors, particularly the ionotropic N-methyl-D-aspartate (NMDA) receptors