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D.BoettgerT.SinghN.GanapathyV

Interestingly, quercetin was shown to effectively reverse these deleterious effects

The presence of ROS stimulates the production of GSH by increasing cystine uptake and promoting the expression of GCL 34

Y.HolbrookC.BrandtM.et al (2015)

In addition, the mRNA for the ECM remodeling enzyme MMP2 was significantly upregulated in the DM_CKD group compared to DM alone and with a trend towards upregulation vs WT, with no significant changes observed in MMP9 but a trend towards increased TIMP1 expression in DM_CKD vs WT as well as DM