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The combination of TMZ and sulfasalazine was shown to be cytotoxic to T98G and A172 cells, and sulfasalazine was found to enhance the cytotoxicity of TMZ to human GBM cells (132)

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These changes reflect enhanced attractive interactions arising from the incorporation of Zn, which introduces localized electrostatic and possible coordination effects that reinforce the binding between GHB and the fullerene cage