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Moreover, PL pro SUb2 provides exquisite specificity for K48-linked diubiquitin chains, which makes diubiquitin a suitable substrate compared with monoubiquitin

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The metabolic and molecular bases of inherited disease

We show that the transition from iPSCs to neurons is accompanied by coordinated changes in mitochondrial function, energy metabolism, and redox balance, with the first week emerging as a decisive period of bioenergetic specialization