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Outcomes: Clozapine metabolite plasma concentrations Summary data for the associations between the selected instrumental variables and plasma concentrations of clozapine metabolite were extracted from the GWAS meta-analysis published by CLOZUK study, consisting of 2,989 individuals of European ancestry ( In the present study, we used three metabolic outcome variables as outcomes, including the plasma concentrations of clozapine and norclozapine and the ratio of clozapine to norclozapine (metabolic ratio)