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This effect was associated with reduced serum levels of proinflammatory cytokines including IL-17 and reduced numbers of Th17 cells[251] Therefore, it appears that both curcumin and resveratrol impact two major inflammatory pathways in our current understanding of autoimmune physiology: TH-17 activation and NF-kB activation

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However, iron overload in patients with hemochromatosis results in excessive PS externalization and calpain activation in RBCs [83]

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