Therefore, mTOR is considered a key gene that negatively regulates autophagy activity not only in cancer but also in endometriosis
Lippincott Williams & Wilkins
Oxygen, beyond being critical for survival, is integral in maintaining equilibrium within cellular environments.48 For individuals without fibromyalgia, consistent and efficient oxygenation of active muscle tissues during various physiological states supports a milieu conducive to pain modulation and general well-being.39 However, the fibromyalgia landscape is characterized by a significant deficiency in oxygenation, precipitating a cascade of events that profoundly affect pain perception.17 This inadequate oxygenation in fibromyalgia patients forms the basis for an increased accumulation of metabolic byproducts within muscle tissues.33 These byproducts, naturally resulting from cellular activities, tend to accumulate in higher concentrations when the oxygen supply fails to satisfy the demands of active muscle tissues.33 The buildup of such metabolic byproducts, including lactate and hydrogen ions, in oxygen-deprived muscle tissues, serves as a trigger for pain receptors, thereby elevating pain sensitivity.49 These substances activate pain receptors, initiating a signaling cascade that intensifies pain perception.50 In conditions of insufficient oxygenation, the cellular environment becomes less efficient at removing these byproducts, creating a milieu that activates pain receptors and significantly contributes to the chronic and widespread pain experienced by fibromyalgia sufferers.51 Moreover, disrupted oxygen delivery in fibromyalgia affects essential cellular processes that play a critical role in pain modulation.13 Oxygen is pivotal in the regulation of neurotransmitters and signaling pathways implicated in pain perception
Terry J
This dual-targeting capability makes Angiopep-2 particularly effective for facilitating nanoparticle transcytosis across the BBB and subsequent uptake by GBM cells (Xin et al
