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Osteo-dystrophy of diabetics in chronic dialysis: a histomorphometric study

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K., Jiang, S., Fu, Y., Nakshatri, H., Ovadia, H

In these individuals it would appear that whilst they were able to exist as relatively healthy individuals, often not knowing that they had methylation associated mutations, some initiating factor such as a prolonged infection, combined with low vitamin D levels resulted in gradual loss of their vitamin B12 supplies leading to the CFS symptomatology being apparent, and the subsequent discovery of their methylation status

It achieves once-daily dosing owing to its prolonged enzyme inhibitory capacity [123, 124], greatly improving medication convenience, though it is associated with a relatively higher incidence of dyskinesia [125]