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In addition, dysregulated -KG flux from normal reductive anabolism via the TCA cycle toward R-2-HG production has been associated with other metabolic flux impairments and disrupted redox balance 119,120 (Fig

Due to their high metabolic demand, cancer cells exhibit fluctuating yet elevated ROS levels compared to non-transformed cells [5]

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2123 Although the roles of iron and lipid peroxidation in ferroptosis have been extensively studied, recent evidence suggests that the regulation of ferroptosis may be more complex and closely associated with iron metabolism rather than being solely dependent on it

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