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As other trichothecenes, verrucarin is neurotoxic, immunotoxic, cytotoxic, potent protein synthesis inhibitor

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The role of the innate immune system has recently come into play as well because investigators reported an upregulation in Toll-like receptor 4 signaling pathways in animal models of osteonecrosis, leading to activation of osteoclasts.103, 104 TABLE 103-4

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