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Nature 311 , 532537 (1984)

Additionally, some RNA molecules may induce hepatotoxicity or renal toxicity due to accumulation in or clearance through the liver and kidneys, respectively, especially with repeated dosing

After O 3 T, the patients in our study showed a decrease in anxiety and depression in (i) the anxiety/depression dimension of the EQ-5D-5L questionnaire and (ii) the HADS-A and HADS-D subscales

Beyond selection, safety biomarkers address another parallel concern

found that LPS engagement with lipopolysaccharide-binding protein (LBP) and CD14 initiates TLR4 signaling that drives oxidative cascades through excessive ROS production (Tuteja et al., 2004)