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It also responds to oxidative stress and hypoxic conditions, common in solid tumors, through mechanisms involving ROS and hypoxia-inducible factors (HIFs) (Figure 1)

140 (2), 444456 (2006) Zayed, O., Hewedy, O.A., Abdelmoteleb, A., Ali, M., Youssef, M.S., Roumia, A.F., Seymour, D., Yuan, Z.C.: Nitrogen journey in plants: from uptake to metabolism, stress response, and microbe interaction

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Robinson T, Wu H, Bugianesi E, Cortez-Pinto H, Doward L, Ekstedt M, Holleboom AG, Oluboyede Y, Ratziu V, Romero-Gomez M, Brass C, Wonders K, Vale L, Anstee QM

A number of metabolic disorders, including dyslipidemia, glucose intolerance, insulin resistance, and obesity, play important roles in the induction of ED, which is particularly prevalent in many middle-aged and elderly patients [7]