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However, upon nutrient deprivation or induced autophagy, their numbers can drop below 50 in a cell

doi: 10.1016/j.cmet.2015.12.006 8 LongJPLiXNZhangF

18 DeewatthanawongR.NockJ

A reasonable bar would be at least one phase 2 RCT in a clinically relevant population (cognitive impairment, mild Alzheimer disease, post-stroke recovery, or similar) showing clinical efficacy with acceptable safety