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This mutation reduces astrocytic Cl levels and trigger apoptosis 323

Discussion The Keap1-Nrf2-ARE signaling pathway is a major balancer of oxidative homeostasis, given its role in oxidative stress response but also physiological regulation 29

Interestingly, prominent hydrogen bonds, formed between the generated amine groups of Metro with the carbonyl oxygen of C P and the amine group of Metro-P3 with carbonyl oxygen of Ser54, provide a rationale for the inhibition of HpTpx red solely by the reduced ligands, explaining why the nitro-prodrugs cannot act as inhibitors of HpTpx

In contrast to glutathione, NAC is efficiently transported into the cell where it is readily converted to L-cysteine for glutathione synthesis

Phenolic compounds are also responsible for the formation of anti-proliferative activity and provide this effect through various mechanisms such as inducing apoptosis, disrupting the cell cycle, altering caspase activities, increasing the number of cells in G 1 phase, and accelerating the expression of p53 and p21 87