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HIF-1 is a well-known regulator that enhances the expression of glucose transporters and glycolytic enzymes and, 186,187 facilitates glucose entry into cells and catabolism, respectively

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After methyl transfer, SAMe is transformed into S-adenosyl-l-homocysteine (SAH), which is then hydrolyzed to Hcy and adenosine

Its established role within peptide research has resulted in extensive investigation across numerous experimental models examining cellular signalling processes