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10.3389/fphar.2025.1545917 226

Each KH domain is separated by variable linker domains with lower sequence conservation

Despite promising preclinical findings, clinical translation of neuroprotective strategies has been limited by persistent conceptual and methodological challenges

Cardiomyocyte fractional shortening, calcium transients Adult mouse left ventricular cardiomyocytes (LVCMs) were loaded with 0.5 M Fura2-AM and placed on the stage of an inverted microscope in a chamber containing normal physiological Tyrodes solution (150 mM NaCl, 5.4 mM KCl, 1.2 mM MgCl 2 , 10 mM glucose, 2 mM Na-pyruvate, 1.8 mM CaCl 2 , and 5 mM HEPES, pH 7.35) 100

Lastly, magnesium sulfate can reduce the absorption of certain drugs due to its laxative effect, which can increase gastrointestinal transit time