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Tumors were allowed to develop for 20 days until they reached a mean cross-sectional area of 0.32 cm 2 , when treatment was initiated with placebo (saline), E 2 (0.3 cm capsule), BSO (4 mmol/kg weight), or BSO (4 mmol/kg weight) plus E 2 (0.3 cm capsule) for an additional 7 days

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