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Under conditions of excess glycine and low serine in colorectal cancer cells, the dominant SHMT reaction is the conversion of glycine to serine, which further depletes one-carbon units and inhibits nucleotide synthesis and proliferation (Labuschagne et al, 2014)

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Curcumin prevents high-fat diet-induced hepatic steatosis in apoe/ mice by improving intestinal barrier function and reducing endotoxin and liver tlr4/nf-b inflammation