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These include primary mitochondrial diseases, multiple acyl-CoA dehydrogenase deficiency (MADD), BrownVialettoVan Laere syndrome (BVVL), as well as more prevalent conditions such as migraine, Parkinsons disease, multiple sclerosis, and cognitive impairment (48)

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Accordingly, current evidence supports their role primarily in research and specialised clinical trials rather than established diagnostic pathways (200202)

Therefore, increased CSF content due to age-related atrophy would generally be compensated for

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