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27 Forms of RP and related diseases include Usher syndrome, 28 Lebers congenital amaurosis, rod-cone disease, Bardet-Biedl syndrome and Refsum disease

Activation of the JAK/STAT3 pathway is a universal feature of astrocyte reactivity in models of different neurodegenerative disorders (Ben Haim et al., in vivo , inhibited this pathway and prevented astrocyte reactivity but also increased the number of mHTT and did not influence neuronal death (Ben Haim et al., 2014)

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These molecules often correspond to secondary metabolites that contribute to the intrinsic therapeutic properties of PDEVs (Zhang et al., 2016)